American Airlines is notifying 469 employees at airports in five U.S. cities that they could be out of work starting in November.
The job losses are a result of the airline's reductions in flights due to high oil prices and the softening economy.
A total of 353 workers at Chicago O'Hare International Airport received the notices.
The remaining notices went to workers in Los Angeles; San Francisco; Raleigh-Durham, North Carolina, and Columbus, Ohio.
American spokeswoman Tami McLallen tells the Fort Worth Star-Telegram letters went to gate and ticket agents, ramp workers, automotive mechanics and airport-based management and support staff.
American's vice president of employee relations, Mark Burdette, said in a letter last week to the Transport Workers Union, that fewer people would be needed to operate the airline as the operating schedule is cut.
Airline officials hope to reduce the number of layoffs with a voluntary early retirement program.