ETMC to participate in global clinical trial for heart failure p - - Tyler, Longview, Jacksonville |ETX News

ETMC to participate in global clinical trial for heart failure patients

From East Texas Medical Center

TYLER, TX - The East Texas Medical Center Cardiovascular Institute has enrolled its first heart failure patient in a clinical trial that uses an implantable device to improve the pumping efficiency of the heart.

“All patients in the trial will receive a cardiac resynchronization therapy (CRT) device, which is a treatment for heart failure called AdaptResponse,” explained Dr. David Dick with Tyler Cardiovascular Consultants. Dr. Dick implanted the first device in an East Texas woman in December and Dr. Raul Torres-Heisecke is the principal investigator for the trial.

The trial is expected to be the largest trial of CRT to date, enrolling approximately 3,000 patients worldwide. In the U.S., approximately 5.1 million people suffer from heart failure. It is the leading cause of hospitalization in people older than 65.

Heart failure means the blood moves through the heart at a slower rate and increases pressure in the heart. As a result, the heart cannot pump enough oxygen and nutrients to meet the body's needs. The chambers of the heart may respond by stretching to hold more blood to pump through the body or become stiff and thickened. This helps to keep the blood moving, but the heart muscle walls may eventually weaken and become unable to pump as efficiently. As a result, the kidneys may respond by causing the body to retain fluid (water) and salt.

The AdaptResponse trial will assess the superiority of the AdaptivCRT feature, which preserves normal heart rhythms and automatically adjusts to patients' needs to customize therapy. Patients in the trial receive a CRT-pacemaker or CRT-defibrillator equipped with the AdaptivCRT algorithm, and will be randomized 1:1 to either treatment (aCRT ON) or control (aCRT OFF) groups. The trial is sponsored by Medtronic.

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