The line is an obvious shot at his Madden contender who called himself "the best corner in the game" after swatting down a pass to San Francisco receiver Michael Crabtree during last season's NFC Championship game.
"I'm opening up the challenge for you to play me in Madden," Newton said.
The video then shows "boog1eVILLE, USA" where Newton shows off his gaming set up for Madden on the Playstation 4 and Xbox 1.
"As you can see, ladies and gentlemen, I have no picks. I am ambidextrous with these thumbs," Newton says.
He continued with his call out to Sherman.
"Richard Sherman, I want to challenge you in a game of Madden. If you don't want to play me, that is cool and that's understandable because these thumbs are official."
Newton then opened up the invitation to "the whole Madden nation."
If you want to play Newton, you can send your gamertag and game console to his Twitter handle (@cameronnewton) or Instagram page (@cameron1newton).
Newton then tells Sherman to call 1-888-CAM-PAIN to play him in Madden.